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KMID : 0363619990200030077
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 3 p.77 ~ p.86
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Effect of Sunghyangchungi-san (Xingxiangzhengqi-san) on Contraction and Lipid Peroxidation Induced by t-Butyl Hydroperoxide in Isolated Rabbit Carotid Artery
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Kim Young-Gyun
Kim Jong-Hoon
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Abstract
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This study was undertaken to evaluate the effect of Sunghyangchungi-san (SHCS) on the oxidant-induced contraction and lipid peroxidation in rabbit carotid artery. Vascular rings isolated from rabbit carotid artery were exposed to t-butyl hydroperoxide (t-BHP), an extrinsic oxidant, and the effect of SHCS on the changes of vascular tension and lipid peroxidation induced by t-BHP was determined. t- BHP induced a slowly developing and sustained contraction of the arterial rings. SHCS effectively relaxed the arterial rings that were pre-contracted by t-BHP. The responses to SHCS were partially dose-dependent at concentrations lower than 0.5 mg/ml. When SHCS was applied prior to the exposure to t-BHP, it inhibited the t-BHP-induced contraction as well. t- BHP increased lipid peroxidation in a dose-dependent manner. SHCS as well as well-known anti-oxidants GSH and DPPD reduced significantly lipid peroxidation induced by t-BHP. SHCS partially blocked the increase in ^{45}Ca uptake induced by t-BHP. In contrast to SHCS, anti-oxidants GSH and DPPD failed to inhibit significantly the t- BHP-induced contraction or ^{45}Ca uptake. From the above results, it is suggested that SHCS relaxed t-BHP-induced contraction of rabbit carotid artery independently of its anti-oxidant action, and inhibition of Ca^{2+} influx may contribute to the underlying mechanism.
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KEYWORD
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Sunghyangchungi-san, lipid peroxidation, oxidant-induced contraction
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